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© 1997 Medical Council on Alcohol

research-article

ANTI-LOW-DENSITY LIPOPROTEIN ANTIBODIES IN ALCOHOLICS WITHOUT AND WITH LIVER DISEASE AND IN SOCIAL DRINKERS

HANNA WEHR*, BOHDAN MILEWSKI1, MONIKA POZNIAK and MARIA RODO

Department of Genetics, Institute of Psychiatry and Neurology, Food and Nutrition Institute Warsaw, Poland
1Department of Metabolic Diseases and Gastroenterology, Food and Nutrition Institute Warsaw, Poland

*Author to whom correspondence should be sent at: Institute of Psychiatry and Neurology, Department of Genetics, al. Sobieskiego 1/9, 02-957 Warsaw, Poland

Received 9 October 1995; first review notified 25 July 1996; accepted 6 August 1996

Antibodies directed to native and to in-vitro acetaldehyde-modified (ethylated) low-density lipoproteins (LDL) were determined in 28 alcoholic subjects divided into two groups: one with do clinical nor laboratory evidence of liver involvement and the second with histologically proven alcohol-related liver disease. The control group consisted of 18 individuals who drank alcohol socially. In the individuals with alcoholic liver disease igG reactivity against both native and ethylated LDL was significantly higher than in alcoholic individuals without liver injury. High levels of IgG reactivity in individuals with alcoholic liver disease were also observed against malondialdehyde-modified, methylated, acetylated and carbamylated LDL. A selective high anti-ethylated LDL IgG reactivity was observed in 11% of control subjects.


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