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© 1997 Medical Council on Alcohol

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CONSTANT ABSOLUTE ETHANOL INTAKE BY SARDINIAN ALCOHOL-PREFERRING RATS INDEPENDENT OF ETHANOL CONCENTRATIONS

CARLA LOBINA, ROBERTA AGABIO, GIACOMO DIAZ1, MAURO FA, FABIO FADDA2, GIAN LUIGI GESSA, ROBERTA REALI and GIANCARLO COLOMBO3,*

‘Bernard B. Brodie’ Department of Neuroscience, University of Cagliari Via Porcell 4, I-09124 Cagliari
1Department of Cytomorphology, University of Cagliari Via Porcell 4, I-09124 Cagliari
2Instirute of Human Physiology, University of Cagliari Via Porcell 4, I-09124 Cagliari
3C.N.R. Centre for Neuropharmacology Via Porcell 4, I-09124 Cagliari, Italy

*Author to whom correspondence should be addressed

Received 1 August 1996; first review notified 20 September 1996; accepted 22 September 1996

The present study was designed to evaluate ethanol drinking behaviour in Sardinian alcohol-preferring (sP) and Sardinian alcohol-non-preferring (sNP) rats in the presence of different ethanol concentrations. Ethanol intake was tested under the two-bottle, free-choice regimen and continuous access schedule. Ethanol-naive sP and sNP rats were initially given ethanol solution at the standard, constant concentration of 10% (v/v) for 8 consecutive days (Phase 1). As expected, daily ethanol intake in sP rats rose from 4 to {small tilde}l6g/kg; in contrast sNP rats consumed <10g/kg/day ethanol. Subsequently, an ascending series of ethanol concentrations, ranging from 3 to 60% (v/v), was presented to sP and sNP rats over a 28-day period (Phase 2). At concentrations varying from 7 to 30%, sP rats consumed constant amounts of absolute ethanol per kg of body weight ({small tilde}6.0 g/kg/day). Daily ethanol intake in sNP rats remained constantly lower than 1.0 g/kg, irrespective of the ethanol concentration. Data from Phase 2 demonstrate the ability of sP rats to precisely adjust daily ethanol intake and support the hypothesis that voluntary ethanol drinking in sP rats is sustained by specific pharmacological effects of ethanol.


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