Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by ULRICHSEN, J.
Right arrow Articles by HEMMINGSEN, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by ULRICHSEN, J.
Right arrow Articles by HEMMINGSEN, R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1996 Medical Council on Alcohol

research-article

NO LOSS OF SOMATOSTATIN-IMMUNOREACTIVE NEURONS IN THE HIPPOCAMPAL DENTATE HILUS OF ALCOHOL-WITHDRAWAL-KINDLED RATS

JAKOB ULRICHSEN*, DAVID P. D. WOLDBYE, CHRISTIAN H. OLSEN, STEVEN HAUGBØL, TOM G. BOLWIG and RALF HEMMINGSEN1

Neuropsychiatric Research Group, Department of Psychiatry Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen
1Department of Psychiatry, Bispebjerg Hospital, Bispebjerg Bakke 23, DK-24OO Copenhagen NV Denmark

*Author to whom correspondence should be addressed

Received 14 October 1995; first review notified 7 March 1996; accepted 19 March 1996

The neuropeptide somatostalin has been suggested to play a role in seizure genesis, electrical kindling and the neurotoxic effects of alcohol. The purpose of the present experiment was to study somatostatin-immunoreactive (SS-IR) neurons in hippocampus during alcohol-withdrawal kindling. Alcohol-withdrawal kindling was performed by subjecting male Wistar rats to seven weekly episodes consisting of 2 days of severe alcohol intoxication and 5 days of alcohol withdrawal. Then the kindled animals (multiple withdrawal group) and a single withdrawal group, which was fed isocaloncally with the kindled animals during episodes 1–7, were exposed to 4 days of severe alcohol intoxication (episode 8). During the following withdrawal, the seizure activity was observed 9–15 h after last alcohol dose, in order to subdivide the animals from these two groups into groups with and without seizures. Subsequently, SS-IR neurons were visualized immunocytochemically and counted in the hilus of the dentate gyms (hippocampus). The number of SS-IR neurons per unit area of the hilus was neither affected by a single nor by multiple episodes of alcohol withdrawal. We therefore concluded that a loss of these neurons is not involved in the development of alcohol-withdrawal-kindled seizures.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Alcohol AlcoholHome page
S. R. HAUGBOL, B. EBERT, and J. ULRICHSEN
UPREGULATION OF GLUTAMATE RECEPTOR SUBTYPES DURING ALCOHOL WITHDRAWAL IN RATS
Alcohol Alcohol., March 1, 2005; 40(2): 89 - 95.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.