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© 1996 Medical Council on Alcohol

research-article

INCREASED CARBOHYDRATE-DEFICIENT TRANSFERRIN DURING PREGNANCY: RELATION TO SEX HORMONES

RUDOLF E. STAUBER*, BARBARA JAUK, PETER FICKERT and MARTIN HÄUSLER1

Departments of Medicine, Karl Franzcns University Auenbruggerplatz 15, A-8036 Graz, Austria
1Gynaecology and Obstetrics, Karl Franzcns University Auenbruggerplatz 15, A-8036 Graz, Austria

*Author to whom correspondence should be addressed

Received 30 October 1995; first review notified 6 February 1996; accepted 22 February 1996

Controversy exists whether carbohydrate-deficient transfernn (CDT) is valuable as a screening tool for fetal alcohol syndrome. We evaluated serum CDT in 60 non-alcohol-abusing women at different stages of normal pregnancy. CDT was weakly related to week of pregnancy and to human placental lactogen. CDT did not correlate with iron, oestradiol or progesterone. By contrast, good correlations were found between transfernn and week of pregnancy or either sex hormone. Using multiple linear regression analysis, only transferrin and week of pregnancy were important predictors of CDT. The diagnostic accuracy of CDT for detecting alcohol abuse may be limited in pregnant women and should be carefully assessed in relation to alcohol consumption.


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