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© 1995 Medical Council on Alcohol

research-article

THE EFFECTS OF ETHANOL, 3,5,3'-TRIIODOTHYRONINE (T3) AND OESTRADIOL (E2) ON THYROID HORMONE NUCLEAR RECEPTOR EXPRESSION IN HUMAN HEPATOCYTE PRIMARY CULTURES

P. BURRA1,2, N. J. S. FITCH2, A. KAPADI2, J. A. FRANKLYN2, M. C. SHEPPARD2, D. B. RAMSDEN2 and E. ELIAS1,*

Department of Medicine, University of Birmingham Birmingham B15 2TH
1Liver Unit, Queen Elizabeth Hospital Birmingham B15 2TH, UK
2Instituto di Medicine Interna, Universita di Padova Italy

*Author to whom correspondence should be addressed

Received 18 February 1994; first review notified 10 July 1994; accepted 8 August 1994

The possibility that ethanol regulated the expression of thyroid hormone receptor mRNA levels was explored in a model involving human hepatocyte primary culture. Ethanol (20.50 and 100 mM for 24h was found to have no effect on the steady-state levels of either triiodothyronine (T3) receptor {alpha}1 or {alpha}2 mRNAs. In contrast both T3(1.10 and 100nM) and oestradiol (0.1, 1 and 10ng/ml) treatments affected either one or both of these mRNA levels in a complex manner, showing that the model was capable of responding to other stimuli. Triiodothyronine receptor ß1 mRNA was not assayed. The hypermetabolic effects of long-term ethanol consumption in humans appears not to be due to the direct effect of ethanol on the regulation of these receptors.


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