Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (45)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by STAUBER, R. E.
Right arrow Articles by KREJS, G. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by STAUBER, R. E.
Right arrow Articles by KREJS, G. J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1995 Medical Council on Alcohol

research-article

EVALUATION OF CARBOHYDRATE-DEFICIENT TRANSFERRIN FOR DETECTION OF ALCOHOL ABUSE IN PATIENTS WITH LIVER DYSFUNCTION

RUDOLF E. STAUBER*, VINZENZ STEPAN, MICHAEL TRAUNER, MARTIE WILDERS-TRUSCHNIG, GEORG LEB and GUENTER J. KREJS

Department of Medicine, Karl Franzens University Auenbruggerplatz 15. A-8036 Graz, Austria

*Author to whom correspondence should be addressed

Received 21 December 1993; first review notified 1 August 1994; accepted 5 September 1994

The determination of carbohydrate-deficient transferrin (CDT) in serum has been suggested as a marker of alcohol abuse. We evaluated serum CDT in 199 patients admitted to our Department of Medicine using a commercially available radioimmunoassay kit for CDT. A history of alcohol consumption was obtained quantitatively by a self-administered questionnaire and qualitatively by the Munich Alcoholism Test. Using a cut-off level of 60 g ethanol per day according to the information from the questionnaire, CDT had a sensitivity of 70% and a specificity of 84%. False-positive values were primarily encountered in cases of hepatic malignoma, primary biliary cirrhosis and chronic hepatitis C. The sensitivity and specificity of CDT was superior to two other markers of chronic ethanol consumption, serum gamma-glutamyltransferase and mean cell volume, and thus proved to be the best single laboratory test for the detection of alcohol abuse.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Alcohol AlcoholHome page
H. Koch, G.-J. Meerkerk, J. O. M. Zaat, M. F. Ham, R. J. P. M. Scholten, and W. J. J. Assendelft
ACCURACY OF CARBOHYDRATE-DEFICIENT TRANSFERRIN IN THE DETECTION OF EXCESSIVE ALCOHOL CONSUMPTION: A SYSTEMATIC REVIEW
Alcohol Alcohol., March 1, 2004; 39(2): 75 - 85.
[Abstract] [Full Text] [PDF]

Home page
 Alcohol AlcoholHome page
T. Laatikainen, H. Alho, E. Vartiainen, P. Jousilahti, P. Sillanaukee, and P. Puska
SELF-REPORTED ALCOHOL CONSUMPTION AND ASSOCIATION TO CARBOHYDRATE-DEFICIENT TRANSFERRIN AND GAMMA-GLUTAMYLTRANSFERASE IN A RANDOM SAMPLE OF THE GENERAL POPULATION IN THE REPUBLIC OF KARELIA, RUSSIA AND IN NORTH KARELIA, FINLAND
Alcohol Alcohol., May 1, 2002; 37(3): 282 - 288.
[Abstract] [Full Text] [PDF]

Home page
 Alcohol AlcoholHome page
P. Sillanaukee, N. Strid, P. Jousilahti, E. Vartiainen, K. Poikolainen, S. Nikkari, J. P. Allen, and H. Alho
Association of self-reported diseases and health care use with commonly used laboratory markers for alcohol consumption
Alcohol Alcohol., July 1, 2001; 36(4): 339 - 345.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
A. Helander, G. Eriksson, H. Stibler, and J.-O. Jeppsson
Interference of Transferrin Isoform Types with Carbohydrate-deficient Transferrin Quantification in the Identification of Alcohol Abuse
Clin. Chem., July 1, 2001; 47(7): 1225 - 1233.
[Abstract] [Full Text] [PDF]

Home page
 Alcohol AlcoholHome page
A. Gomez, A. Conde, J. A. Aguiar, J. M. Santana, A. Jorrin, and P. Betancor
Diagnostic usefulness of carbohydrate-deficient transferrin for detecting alcohol-related problems in hospitalized patients
Alcohol Alcohol., May 1, 2001; 36(3): 266 - 270.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
T. Arndt, R. Hackler, T. Muller, T. O. Kleine, and A. M. Gressner
Increased serum concentration of carbohydrate-deficient transferrin in patients with combined pancreas and kidney transplantation
Clin. Chem., February 1, 1997; 43(2): 344 - 351.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.