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© 1995 Medical Council on Alcohol

research-article

CAROTENOID, RETINOID AND VITAMIN E STATUS OF THE OROPHARYNGEAL MUCOSA IN THE ALCOHOLIC

M. A. LEO, H. K. SEITZ1, H. MAIER2 and C. S. LIEBER*

Section of Liver Disease and Nutrition, and Alcohol Research and Treatment Center Bronx VA Medical Center, 130 West Kingsbridge Road, Bronx, New York, NY 10468 and Mount Sinai School of Medicine, City University of New York New York, NY 10029, USA
1Laboratory of Alcohol Research, Liver Disease and Nutrition, Department of Medicine, Salem Medical Center (Teaching Hospital, University of Heidelberg) Heidelberg, Germany
2Department of Otorhinolaryngology, University of Heidelberg Heidelberg, Germany

*Author to whom correspondence should be addressed

Received 10 January 1994; first review notified 30 April 1994; accepted 23 May 1994

Concentrations of carotenoids, retinoids and tocopherols were determined in the homogenate of macroscopically normal appearing oropharyngeal mucosa from 10 chronic alcoholics and from 11 control patients. All the alcoholics except one had oropharyngeal cancer. No significant difference was found in tissue levels of carotenoids and tocopherols between alcoholics and controls. Furthermore, in seven of 11 controls, retinol was undetectable in the oropharyngeal mucosa, while in the alcoholics only two out of 10 had unmeasurable retinol levels. These results do not support the concept that ethanol-associated oropharyngeal carcinogenesis is due, at least in part, to local deficiencies in retinoids, carotenoids or {alpha}-tocopherols.


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