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© 1994 Medical Council on Alcohol

research-article

EFFECT OF S-ADENOSYL-L-METHIONINE ADMINISTRATION ON RED BLOOD CELL CYSTEINE AND GLUTATHIONE LEVELS IN ALCOHOLIC PATIENTS WITH AND WITHOUT LIVER DISEASE

C. LOGUERCIO*, G. NARDI{dagger}, F. ARGENZIO{ddagger}, C. AURILIO{ddagger}, E. PETRONE{ddagger}, A. GRELLA{ddagger}, C. DEL VECCHIO BLANCO{ddagger} and M. COLTORTI§

*Cattedra di Gastroenterologia, Facoltà di Medicina, II Università di Napoli, Italy
{dagger}Laboratono di Biochimica, Stazione Zoologica ‘Anton Dohm’, Napoli, Italy
{ddagger}Servizio di Tossicologia d'Urgenza Medicina, II Università degli Studi di Napoli, Italy
§Cattedra di Clinica Medica II, Facoltà di Medicina, II Università degli Studi di Napoli, Italy

Received 22 July 1993; first review notified 30 December 1994; accepted 19 January 1994

We measured glutathione and cysteine concentrations in erythrocytes of chronic alcohol misusers with (20 subjects) and without liver cirrhosis (20 subjects). Glutathione levels were decreased, whereas those of cysteine were increased in all patients. Parenteral treatment with S-adenosyl methionine (SAME); (2 g daily in 250 ml 0.15 M NaCl for 15 days) corrected the erythrocyte thiol alterations. We conclude that parenteral treatment with SAME affects the metabolism of SH compounds in erythrocytes of alcoholic patients.


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