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© 1994 Medical Council on Alcohol

research-article

ALCOHOL CONSUMPTION BY NURSING RATS AND ITS EFFECT ON THE CEREBELLUM OF THE OFFSPRING

JAVAD HEKMATPANAH, NASRIN HAGHIGHAT and CAMERON R. ADAMS

University of Chicago Medical Center, 5841 South Maryland Box 405, Chicago, IL 60637, U.S.A.

Received 8 February 1994; accepted 21 December 1994

To study the effect of alcohol on Purkinje cells and on myeination of the cerebellum of neonate rats, female Sprague-Dawley rats were fed alcohol (ethanol) during their nursing period. The alcohol was given in amounts of 5% or 10% per volume of drinking water. Food and liquids, equal in calories, were distributed among darns receiving alcohol. One group of control rats received similar diet but no alcohol. The results were then compared with those of a second group of controls, receiving no alcohol but having access to unlimited supplies of food and water. Histological examination of pups revealed degenerative changes in Purkinje cells and delayed myelination of the cerebellum.


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