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© 1994 Medical Council on Alcohol

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RAPID EVALUATION OF ETHANOL CONTENT AND METABOLISM IN HUMAN PLASMA USING QUANTITATIVE PROTON MAGNETIC RESONANCE SPECTROSCOPY

A. DAVIN, J. VION-DURY, P. VIOUT and P. J. COZZONE*

Centre de Résonance Magnétique Biologique et Médicale (URA CNRS 1186), Faculté de Médecine de Marseille 27, Boulevard Jean Moulin, 13005 Marseille, France

*Author to whom correspondence should be ddressed

Received 14 June 1994; first review notified 11 July 1994; accepted 12 July 1994

Proton magnetic resonance spectroscopy (MRS) was used to assay ethanol in plasma. Ethanol concentrations determined by MRS and conventional enzymatic methods are in excellent agreement. In addition to ethanol, acetone, acetate and ß-hydroxybutyrate can be quantified simultaneously in the same sample. Proton MRS of plasma offers a rapid evaluation of human ethanol metabolism and may be useful in screening for chronic alcoholism.


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