Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (5)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by SHINOHARA, T.
Right arrow Articles by AMENO, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by SHINOHARA, T.
Right arrow Articles by AMENO, K.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1993 Medical Council on Alcohol

research-article

A COMPARATIVE STUDY OF ETHANOL ABSORPTION IN THE CANINE JEJUNUM AFTER PRETREATMENT WITH CYANAMIDE OR PYRAZOLE

TOYOHIKO SHINOHARA, IWAO IJIRI, SETSUKO AMENO, CHIAKI FUKE and KIYOSHI AMENO

Department of Forensic Medicine, Kagawa Medical School 1750-1, Miki-Cho, Kita-Gun, Kagawa 761-07, Japan

Received 24 July 1992; accepted 20 December 1992

This report describes the retardation of ethanol absorption from the intestinal tract and reduction of portal blood flow by high acetaldehyde concentrations in dogs using a jejunal segment with the vascular supply intact. The cyanamide-pretreatment group (CY), in which an extremely high acetaldehyde concentration developed, in comparison with the control and pyrazole-pretreated (PY) groups, showed a gradual increase of portal blood ethanol, a 25% reduction in the amount of absorbed ethanol, and an 85% smaller absorption rate constant value (Ka). These facts indicate that the presence of a high acetaldehyde concentration in the blood results in a reduction of ethanol absorption and retardation of ethanol reaching the systemic circulation. The rapid reduction of portal blood flow and the lower ethanol level in the portal vein observed in the CY group, in comparison with the other two groups, also indicate that the reduction of ethanol permeability through the absorption site to the blood is an important retarding factor induced by acetaldehyde.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Alcohol AlcoholHome page
H. Kinoshita, I. Ijiri, S. Ameno, T. Kubota, X. Zhang, S. Hishida, and K. Ameno
CHOLINERGIC NERVES MEDIATE ACETALDEHYDE ACTION IN THE GASTROINTESTINAL TRACT
Alcohol Alcohol., September 1, 2001; 36(5): 377 - 380.
[Abstract] [Full Text] [PDF]

Home page
 Alcohol AlcoholHome page
H. Kinoshita, D. S. Jessop, D. P. Finn, T. L. Coventry, D. J. Roberts, K. Ameno, I. Jiri, and M. S. Harbuz
Acetaldehyde, a metabolite of ethanol, activates the hypothalamic-pituitary-adrenal axis in the rat
Alcohol Alcohol., January 1, 2001; 36(1): 59 - 64.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.