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© 1993 Medical Council on Alcohol

research-article

CYANAMIDE ON ETHANOL INTAKE: HOW DOES IT REALLY WORK?

CARLOSM M. G. ARAGON, KAREN SPIVAK, BRIAN R. SMITH and ZALMAN AMIT*

Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University 1455 de Maisonneuve Boulevard West, Montreal, Quebec, Canada, H3G 1M8

*Author to whom correspondence should be addressed

Received 13 July 1992; first review notified 5 October 1992; accepted 15 November 1992

Cyanamide, an aldehyde dehydrogenase inhibitor, has been shown to suppress voluntary ethanol consumption in animals. Studies were carried out to compare the effect of cyanamide on ethanol, saccharin-quinine and water intake in a restricted (10 min) access and in a free-choice nonrestricted access paradigm. An immediate and constant increase in fluid consumption was observed in the restricted access schedule paradigm independent of the fluid tested as cyanamide affected the consumption of all fluids including water. In the nonrestricted access study, cyanamide significantly increased total fluid intake. However, while saccharin-quinine-drinking animals treated with cyanamide demonstrated no change in intake preference, ethanol consumption was suppressed with a concomitant decrease in preference for ethanol. The present findings suggested that cyanamide may possess at least two, paradigm-specific, independent properties. It may enhance the consumption of fluid in general; however, it may also have a specific effect on ethanol intake when animals have continuous ethanol availability.


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