Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by JOLY, J. P.
Right arrow Articles by MARTIN, J. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by JOLY, J. P.
Right arrow Articles by MARTIN, J. P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1992 Medical Council on Alcohol

research-article

SERUM TRYPSIN-LIKE ACTIVITY IN CHRONIC ALCOHOLIZED MEN: POSSIBLE RELATIONSHIP WITH LIPIDS, apoA-1 AND apoB LIPOPROTEINS

J. P. JOLY*,{dagger}, R. SESBOÜÉ{ddagger}, B. HILLEMAND{dagger} and J. P. MARTIN{ddagger}

{dagger}Centre d'Hygiène Alimentaire, C.H.U. Rouen Bois-Guillaume, France
{ddagger}Institut National de la Santé et de la Recherche Médicale Unité 295, Saint-Etienne du Rouvray, France

* Author to whom correspondence should be addressed, at: CHR, La Colombière, Avenue Maréchal Juin, 76230 Bois-Guillaume, France.

Received 18 May 1992; accepted 9 June 1992

Chronic alcoholization is known to increase plasma trypsin levels. One-hundred and forty-six male chronic alcohol users were tested for serum trypsin-like activity (STA), total cholesterol (TC), LDL-cholesterol (LDL-C), HDL-/cholesterol (HDL-C), triglycerides (TG), apoA-1 and apoB lipoproteins. STA was positively correlated to LDL-C, TG and apoB rates and the CT/HDL-C index and negatively correlated to HDL-C and apoA-1 rates and the apoA-1/ apoB index. Eighty-four patients with high STA (group B) compared to 62 patients with normal STA (group A) showed significantly higher LDL-C, TG, apoB rates and TC/HDL-C index contrasting with significantly lower HDL-C and apoA-1 rates and the apoA-1/apoB index. The two groups were matched for age, overweight, cigarette smoking and glycemia. Hepatic dysfunction does not explain the differences in the lipoproteic parameters. Such results would suggest that there may be a tryptic alteration of apoproteins in vivo as already demonstrated in vitro and experimentally suspected in vivo in some other studies. Competition by the trypsinactivated {alpha}2 macroglobulin for the chylomicron-remnant LDL receptor-related protein may be evoked.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.