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© 1992 Medical Council on Alcohol

research-article

TRH TEST IN ALCOHOLICS: RELATIONSHIP OF THE ENDOCRINE RESULTS WITH NEURORADIOLOGICAL AND

NEUROPSYCHOLOGICAL FINDINGS

CARLO MARCHESI{dagger},*, CARLO DE RISIO*, GINO CAMPANINI*, CARLO MAGGINI*, PAOLO PIAZZA{ddagger}, MARIO GRASSI§, PAOLO CHIODERA| and VITTORIO COIRO

*Institutes of Clinical Psychiatry, University of Parma 43100 Parma, Italy
{ddagger}Institutes of Neuroradiology, University of Parma 43100 Parma, Italy
§Biostatistics Unit, University of Pavia 27100 Pavia, Italy
|Institutes of Endocrinology, University of Parma 43100 Parma, Italy
Institutes of Medical Clinic, University of Parma 43100 Parma, Italy

{dagger}Author to whom correspondence should be addressed at: University di Parma, Istituto di Clinica Psichiatrica, P. zle Matteotti 9, 43100 Parma, Italy.

Received 29 October 1991; accepted 20 May 1991

Neuroradiological, neuropsychological and neuroendocrine parameters were evaluated in 20 non-depressed alcoholic men after 4 weeks (N = 11) or after at least 1 year (N = 9) of abstinence from alcohol and in normal men (N = 9). With regard to normal controls, 4-week abstinent alcoholics showed larger lateral and third ventricles, without modification in the number of cerebral sulci, and altered scores of tests evaluating subcortical and frontal function. Furthermore, in these patients the TSH (thyroid stimulating hormone) and PRL (prolactin) responses to thyrotropin releasing hormone were higher than in controls, suggesting a reduced hypothalamic control of TSH and PRL secretion. Taken together, these findings suggest the presence of a frontal-subcortical disorder in alcoholics. Patients who had been abstinent from alcohol for at least 1 year were not distinguishable from controls for neuroradiological, neuropsychological and neuroendocrine findings, suggesting that the alcohol-related brain alterations are reversible after a long period of abstinence.


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