Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (13)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by TALLAKSEN, C. M. E.
Right arrow Articles by BØHMER, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by TALLAKSEN, C. M. E.
Right arrow Articles by BØHMER, T.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1992 Medical Council on Alcohol

research-article

THE CONCENTRATION OF THIAMIN AND THIAMIN PHOSPHATE ESTERS IN PATIENTS WITH ALCOHOLIC LIVER CIRRHOSIS

C. M. E. TALLAKSEN, H. BELL and T. BØHMER

Department of Medicine, Aker University Hospital 0514 Oslo, Norway

Received 15 May 1992; first review notified 30 June 1992; accepted 28 July 1992

The blood and plasma concentrations of thiamin and thiamin phosphate esters were determined concomitantly by high-performance liquid chromatography (HPLC) in 22 patients with alcoholic liver cirrhosis, and also in 10 of them 24 hr after a 100 mg thiamin i.m. injection. Sixteen patients were abstaining from alcohol at the time of the study, 6 were currently misusing alcohol. The control group included 30 healthy volunteers, of whom 10 were given the same thiamin injection as the patients. Blood thiamin diphosphate was the only compound decreased in the abstaining patients compared to controls (70.9 ± 21.9 nmol/l vs. 84.4 ± 19.0 nmol/l), but all thiamin compounds in blood and plasma were decreased in the misusing patients. All thiamin compounds (except blood monophosphate) were also significantly lower in the misusing than in the abstaining patients (plasma thiamin: 5.3 ± 1.3 vs. 11.7 ± 8.3 nmol/l; plasma monophosphate: 1.0 ± 1.1 vs. 4.1 ± 2.9 nmol/l; blood diphosphate: 45.7 ± 18.3 vs. 70.9 ± 21.9 nmol/l). Thiamin phosphorylation ratio was decreased in the thiamin administration compared to controls (2.83 ± 0.74 vs. 3.68 ± 0.58). Plasma thiamin was higher in the abstaining patients than in the controls (11.7 ± 8.4 nmol/l vs. 7.3 ± 2.5 nmol/l), and above the mean + 2 SD of the controls in 31% of the abstaining patients. In conclusion, current ethanol misuse is associated with low thiamin concentrations, and liver cirrhosis is associated with a decreased thiamin diphosphate concentration and thiamin phosphorylation.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Alcohol AlcoholHome page
A. D. THOMSON and E. J. MARSHALL
THE NATURAL HISTORY AND PATHOPHYSIOLOGY OF WERNICKE'S ENCEPHALOPATHY AND KORSAKOFF'S PSYCHOSIS
Alcohol Alcohol., March 1, 2006; 41(2): 151 - 158.
[Abstract] [Full Text] [PDF]

Home page
 Alcohol AlcoholHome page
L. C. Hope, C. C. H. Cook, and A. D. Thomson
A SURVEY OF THE CURRENT CLINICAL PRACTICE OF PSYCHIATRISTS AND ACCIDENT AND EMERGENCY SPECIALISTS IN THE UNITED KINGDOM CONCERNING VITAMIN SUPPLEMENTATION FOR CHRONIC ALCOHOL MISUSERS
Alcohol Alcohol., November 1, 1999; 34(6): 862 - 867.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.