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© 1992 Medical Council on Alcohol

research-article

METADOXINE (PYRROLIDONE CARBOXYLATE OF PYRIDOXINE) ANTAGONIZES THE LOCOMOTOR-STIMULATORY EFFECT OF ETHANOL IN MICE

BRUNO GARAU*, FABIO FADDA*,{dagger}, FRANCO MELIS*, ENZA GELSO{ddagger} and GIAN LUIGI GESSA*

*Department of Neuroscience, University of Cagliari Via Porcell 4, 1-09124 Cagliari, Italy
{ddagger}Department of Neuroscience, Laboratori Baldacci Pisa, Italy

{dagger}Author to whom correspondence should be addressed.

Received 9 March 1992; accepted 1 June 1992

The effects of metadoxine (pyrrolidone-carboxylic acid; PCA) and pyridoxine on the locomotor responses to ethanol in mice were compared. Metadoxine (200 and 400 mg/kg i.p.) and PCA (86 and 172 mg/kg) prevented, in a dose-related manner, the locomotor stimulant effect of a low dose of ethanol (1.5 g/kg i.p.), whereas pyridoxine (228 mg/kg i.p.) was completely ineffective. Neither compound modified the sedative effect of a high ethanol dose (2.5 g/kg i.p.). The results indicate that the antagonistic effect of metadoxine on ethanol stimulant response is due to the PCA component of the molecule.


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