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© 1992 Medical Council on Alcohol

research-article

RELATIONSHIP BETWEEN BLOOD CATALASE ACTIVITY AND DRINKING HISTORY IN A HUMAN POPULATION, A POSSIBLE BIOLOGICAL MARKER OF THE AFFINITY TO CONSUME ALCOHOL

ULRIKE M. KOECHLING and ZALMAN AMIT*

Center for Studies in Behavioral Neurobiology, Concordia University 1455 de Maisonneuve Blvd. W., H-1013, Montreal, Quebec H3G 1M8, Canada

*Author to whom correspondence should be addressed.

Received 27 July 1991; accepted 17 December 1991

The relationship between blood catalase activity and alcohol consumption was investigated in a group of Caucasian volunteers (N = 191). Subjects individually attended a 1-hr session, during which they were asked to complete the Michigan Alcoholism Screening Test (MAST) and MacAndrew Scale (MAC), supply information on alcohol consumption (averaged over the most recent and typical 30-day periods: Recent and Typical Q-Values) and other drug use by answering the Concordia Alcohol Screening Questionnaire (CASQ), and provide a 100-µl blood sample from the fingertip. Results showed a significant positive relationship between typical Q-Value and catalase activity (r = 0.43, P < 0.001), which improved after eliminating multiple drug users from the analysis (r = 0.65, P < 0.001). Multiple regression analyses showed that catalase activity combined with being male, using cocaine or crack, scoring highly on the MAC scale and having alcohol-related problems (MAST), explained a significant portion of the variance in Typical Q-Value. These results support the notion that catalase activity is a strong positive determinant of alcohol intake and support the hypothesis that the enzyme catalase plays a role in regulating voluntary ethanol consumption.


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