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© 1992 Medical Council on Alcohol

research-article

MODIFICATION OF THE BEHAVIOURAL EFFECTS OF ETHANOL BY NIFEDIPINE

JASON M. WHITE and ANGELA M. SMITH

Department of Clinical and Experimental Pharmacology, University of Adelaide G.P.O., Box 498, Adelaide, S.A. 5001, Australia

Received 4 September 1991; accepted 9 December 1991

Nifedipine (10.0 mg/kg) was administered to mice together with graded doses of ethanol (0, 2.5, 3.0, 3.5, 4.0 and 4.5 g/kg), and activity measured over a 2-hr period following administration. Low ethanol doses increased activity, whereas the highest dose decreased it. By itself, nifedipine had no effect on activity, but when combined with ethanol it produced a consistent decrease in comparison with ethanol alone. This occurred irrespective of whether the ethanol dose alone increased or decreased activity. These results demonstrate a clear interaction between nifedipine and ethanol which cannot be characterized as simple potentiation or antagonism. Time-course data showed that the effects of nifedipine were apparent within 10–20 min of drug administration, but, in the case of the highest ethanol dose, increased toward the end of the 2-hr period. Retardation of the development of acute tolerance may contribute to the interaction between ethanol and nifedipine.


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