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© 1992 Medical Council on Alcohol

research-article

RAPID COMMUNICATION: ALCOHOL-PREFERRING RATS HAVE FEWER DOPAMINE D2 RECEPTORS IN THE LIMBIC SYSTEM

ENNIO STEFANINI, MICHELA FRAU, MARIA GIULIA GARAU, BRUNO GARAU, FABIO FADDA and GIAN LUIGI GESSA*

‘Bernard B. Brodie’ Department of Neuroscience, University of Cagliari via Porcel 14, 09124 Cagliari, Italy

*Author for correspondence.

Received 19 November 1991; accepted 10 January 1992

Dopamine D2 receptors in nucleus accumbens, olfactory tubercle and caudate nucleus of Sardinian ethanol-preferring (SP), and non-preferring (SNP) rats were compared by using [3H]YM-09151-2 binding. SP rats exhibited, in each area, lower density of D2 receptors than SNP and unselected Wistar (UW) rats. The results suggest that reduction in D2 receptors in SP rats may be relevant to their innate preference for alcohol.


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