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© 1992 Medical Council on Alcohol

research-article

RAPID COMMUNICATION: TIANEPTINE, A SPECIFIC SEROTONIN UPTAKE ENHANCER, DECREASES ETHANOL INTAKE IN RATS

M. DAOUST*, P. COMPAGNON*, E. LEGRAND* and E. MOCAËR{dagger}

*Pharmacologie, Faculté de Médecine et de Pharmacie de Rouen B.P. 97, 76803 Saint Etienne du Rouvray, Cedex
{dagger}I.R.I.S., Courbevoie France

Received 25 October 1991; accepted 11 November 1191

The effect on ethanol intake of the selective 5-HT uptake enhancer tianeptine was examined in rats and compared with that of fluoxetine, a specific 5-HT uptake inhibitor. Both treatments significantly decreased ethanol intake (54% by tianeptine and 57% by fluoxetine). Fluoxetine also decreased food intake whereas tianeptine did not. Body weight was decreased by 12.5% in fluoxetine-treated rats but was not modified by tianeptine. It is proposed that tianeptine has a specific action on ethanol intake, possibly related to its effect on serotonin function.


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