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© 1991 Medical Council on Alcohol

research-article

SUPERSENSITIVITY TO GABA IN THE TRANSMURALLYSTIMULATED VAS DEFERENS ISOLATED FROM ETHANOL-DEPENDENT MICE

RICARDO TABACH and SERGIO DE MORAES*

Department of Pharmacology, Institute of Biomedical Science, University of Sao Paulo CEP 05508, Sao Paulo, Brazil

*Author for correspondence

Received 10 March 1990; accepted 18 February 1991

The effects of ethanol dependence on the sensitivity of the transmurally-stimulated mouse vas deferens to gamma-aminobutric acid (GABA), noradrenaline and histamine were studied Tissues isolated from ethanol-dependent mice showed supersensitivity to the twitch inhibitory effect of GABA. Sensitivity to noradrenaline and histamine was not significantly altered Exposure to ethanol in vitro significantly increased the sensitivity of the isolated mouse vas deferens to the inhibitory effect of histamine, noradrenaline and GABA. Pretreatment of vasa deferentia isolated from ethanol-dependent mice with bicuculline did not block the ethanolinduced supersensitivity to GABA, and naloxone was without effect on the supersensitivity to GABA observed in the transmurally-stimulated mouse vas deferens. It is concluded that ethanol dependence induces supersensitivity of the transmurally-stimulated mouse vas deferens to GABA, which is mediated by a bicuculline and naloxone-insensitive GABA receptor.


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