Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by ULRICHSEN, J.
Right arrow Articles by HEMMINGSEN, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by ULRICHSEN, J.
Right arrow Articles by HEMMINGSEN, R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1991 Medical Council on Alcohol

research-article

ACIDIC PHOSPHOLIPIDS IN SYNAPTOSOMAL PLASMA MEMBRANES DURING REPEATED EPISODES OF PHYSICAL ETHANOL DEPENDENCE IN THE RAT

J. ULRICHSEN*, L. GUSTAVSSON{dagger}, C. ALLING{dagger}, L. CLEMMESEN* and R. HEMMINGSEN{ddagger},§

*Department of Psychiatry, Neurobiological Research Group Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100 Ø, Denmark
{dagger}Department of Psychiatry and Neurochemistry, University of Lund Sweden
{ddagger}Department of Psychiatry E . Bispebjerg Hospital, University of Copenhagen Bispebjerg Bakke 23, DK 2400 NV, Denmark

§Author to whom correspondence should be addressed

Received 26 September 1990; accepted 19 April 1991

The effects of repeated episodes of ethanol intoxication and the hyperexcitablc state of withdrawal on the synaptosomal concentration of acidic phospholipids were studied in rats. There was no indication that cumulative changes in the synaptosomal acidic phospholipid composition in general occurred during multiple episodes of ethanol intoxication and withdrawal. There was, however, a statistically significant decrease in acidic phospholipid concentration (phosphatidylinositol; PI) in synaptosomal membranes from animals revealing spontaneous convulsive behaviour during ethanol withdrawal Hypothetically this may reflect an inability to increase acidic phospholipid membrane content and thus to adaptively increase the seizure threshold during withdrawal.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.