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© 1991 Medical Council on Alcohol

research-article

DISTURBANCES IN MYOCARDIAL CREATINE KINASE FOLLOWING ETHANOL ADMINISTRATION TO RATS — TRIALS OF PREVENTION BY ALLOPURINOL, DESFERRIOXAMINE AND PROPRANOLOL

ISABELLE HININGER, CATHERINE RIBIERE* and ROGER NORDMANN

Department of Biomedical Research on Alcoholism. Université René Descartes 45 rue des Saints-Pères, 75270 Paris Cedex 06. France

*Author for correspondence

Received 7 March 1991; accepted 1 May 1991

A significant decrease in myocardial creatine kinase (CK) activity is apparent 2 hr after an acute ethanol load (2 3 g/kg. i p ) in the rat A lower dose (1 15 g/kg. i.p ). as well as ethanol addition in vitro up to 50 mM. do not affect this activity Pretreatment with allopunnol (146 µmol/kg. i.p) given at 16 hr and at 30 mm before ethanol (2.3 g/kg) or with desfemoxamine (152 µmol/kg. i p ) 30 min before ethanol failed to prevent the ethanol-induced decrease in CK activity By contrast, propranolol (17 µmol/kg. i.p ). administered 30 min before ethanol elicited an enhanced CK activity in both control and ethanol-treated rats This finding is likely related to the ß-blocking action and/or anlioxidant properties of propranolol Chronic ethanol intake (18% in calories) for 4 weeks also induced a decrease in myocardial CK activity, which could play a role in the pathogenesis of alcoholic cardiomyopathy


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