Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by MASCORD, D.
Right arrow Articles by WHITFIELD, J. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by MASCORD, D.
Right arrow Articles by WHITFIELD, J. B.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1991 Medical Council on Alcohol

research-article

THE EFFECT OF FRUCTOSE ON ALCOHOL METABOLISM AND ON THE [LACTATE]/[PYRUVATE] RATIO IN MAN

D. MASCORD, J. SMITH*, G. A. STARMER and J. B. WHITFIELD*,{dagger}

Department of Pharmacology, University of Sydney NSW 2006
*Department of Clinical Biochemistry, Royal Prince Alfred Hospital Camperdown NSW 2050, Australia

{dagger}To whom correspondence should be addressed.

Received 13 March 1990; first review notified 26 September 1990; accepted 26 October 1990

Ten male subjects were given alcohol by intravenous infusion and maintained at a constant blood alcohol level. The rate of alcohol metabolism was measured before and after an oral dose of fructose (100 g), as the amount of alcohol required to maintain the steady state. The mean rate of alcohol metabolism increased by 80% after fructose but there was considerable variation among the subjects, which was related to their plasma fructose concentrations. Blood lactate increased after fructose to a greater degree than blood pyruvate, resulting in a significant increase in [lactate]/[pyruvate] ratio. Since fructose increased the [lactate]/[pyruvate] ratio when it increased alcohol metabolism, the action of fructose cannot be explained by a decrease in the liver cytoplasmic [NADH]/[NAD] ratio and some other mechanism must be sought.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Exp. Biol.Home page
F. Sanchez, B. P. Kotler, C. Korine, and B. Pinshow
Sugars are complementary resources to ethanol in foods consumed by Egyptian fruit bats
J. Exp. Biol., May 1, 2008; 211(9): 1475 - 1481.
[Abstract] [Full Text] [PDF]

Home page
 Alcohol AlcoholHome page
R. Vonlanthen, J. H. Beer, and B. H. Lauterburg
EFFECT OF METHYLENE BLUE ON THE DISPOSITION OF ETHANOL
Alcohol Alcohol., September 1, 2000; 35(5): 424 - 426.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.