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© 1990 Medical Council on Alcohol

research-article

SELECTIVE ANTAGONISTIC EFFECTS OF EXPOSURE TO BRIGHT LIGHT ON THE HYPOTHERMIC ACTION OF ETHANOL

DAVID H. OVERSTREET*, STEVEN C. DILSAVER{dagger}, AMIR H. REZVANI*,{ddagger} and DAVID S. JANOWSKY{dagger}

*Center for Alcohol Studies and Department of Psychiatry, University of North Carolina Chapel Hill, NC 27514
{dagger}Department of Psychiatry, Ohio State University Columbus, OH 43210-1228, U.S.A.

{ddagger}To whom correspondence should be addressed at: Center for Alcohol Studies, School of Medicine CB #7175, University of North Carolina, Chapel Hill, NC 27514, U.S.A.

Received 22 December 1989; accepted 6 July 1990

Flinders Sensitive and Resistant Lines of rats, which are differentially sensitive to the hypothermic effects of both muscarinic agonists and ethanol, were exposed to full spectrum artificial bright light for eight days, because exposure to bright light has been shown to blunt hypothermic responses to muscarinic agonists. There was a selective blunting of the hypothermic effects of ethanol, but no significant change in the intoxicating effects of ethanol, as measured by evaluation of the righting reflex. The selective effect of exposure to bright light on the hypothermic actions of ethanol suggests that bright light may be modifying the function of only a limited number of brain regions, including the hypothalamus.


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