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© 1990 Medical Council on Alcohol

research-article

GENOTYPING STUDY OF ALCOHOL DEHYDROGENASE CLASS I POLYMORPHISM IN FRENCH PATIENTS WITH ALCOHOLIC CIRRHOSIS

PATRICE COUZIGOU*,{dagger}, BENOÎT FLEURY{dagger}, ALEXIS GROPPI{ddagger}, ANDRÉ CASSAIGNE§, JOËL BEGUERET{ddagger}, ALBERT IRON§,{ddagger} and The French Group for Research on Alcohol and Liver||

{dagger}Department of Hepatogastroenterology, Haut-Lévêque Hospital 33604 Pessac
{ddagger}Department of Genetics, University Bordeaux II 33076 Bordeaux, France
§Department of Biochemistry, University Bordeaux II 33076 Bordeaux, France

*To whom reprint requests should be addressed.

Received 10 February 1990; first review notified 11 June 1990; accepted 12 July 1990

Comparison of alcohol dehydrogenase polymorphism at the loci ADH2 and ADH3 is made in France between 46 alcoholic cirrhotic patients and 39 controls, by genotyping technique using polymerase chain reaction on blood microsample collected on blotting paper. The genotype distributions are similar, with low frequency of the ADH22 allele. Polymorphism at the ADH3 locus is not a genetic factor for alcoholic cirrhosis in France.


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