Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by WAGNER, J. G.
Right arrow Articles by GANES, D. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by WAGNER, J. G.
Right arrow Articles by GANES, D. A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1989 Medical Council on Alcohol

research-article

PARAMETERS Vm'. AND Km FOR ELIMINATION OF ALCOHOL IN YOUNG MALE SUBJECTS FOLLOWING LOW DOSES OF ALCOHOL

JOHN G. WAGNER*,{dagger}, PAUL K. WILKINSON{ddagger} and DEREK A. GANES{ddagger}

*College of Pharmacy and Department of Pharmacology and Upjohn Centre for Clinical Pharmacology, Medical School, The University of Michigan AM Arbor, MI 48109, U.S.A.
{ddagger}College of Pharmacy, The University of Michigan Ann Arbor, MI 48109, U.S.A.

{dagger}Author for correspondence. Present address: Research and Development Center, R. P. Scherer Corporation, Ann Arbor, MI 48108, U.S.A.

Received 9 January 1989; accepted 13 June 1989

Seventy-four (44 under fasting conditions and 30 following oral liquid meals) sets of post-absorptive human capillary blood alcohol concentration-time data were computer-fitted to the integrated form of the Michaelis-Menten equation by numerical integration by nonlinear least squares to provide 74 pairs of the kinetic Vm' and Km, parameter values. The parameters were highly correlated (r = 0.915) by orthogonal least squares. Eight of the fasting subjects received four different oral doses of alcohol and fourteen subjects each received three different alcohol treatments. Intra-subject variances of Vm', Km, and the ratio Vm', Km were calculated from the multiple treatments. Inter-subjed variances were calculated from the 22 mean values of each parameter. Each parameter and the intra-subject variances of the parameters were found to be log normally distributed. The Liquid meals (carbohydrate, fat and protein separately) appeared not to affect the parameter values. The computer fittings were all excellent as evidenced by the relatively small standard deviations of the estimated parameters and other statistical measures of fit.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Pharmacol. Exp. Ther.Home page
D. G. McCarver, H. R. Thomasson, S. S. Martier, R. J. Sokol, and T.-K. Li
Alcohol Dehydrogenase-2*3 Allele Protects Against Alcohol-Related Birth Defects Among African Americans
J. Pharmacol. Exp. Ther., December 1, 1997; 283(3): 1095 - 1101.
[Abstract] [Full Text]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.