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© 1989 Medical Council on Alcohol

research-article

STUDIES ON ALDEHYDE DEHYDROGENASE TYPE V-A ISOZYMES IN LIVER DISEASE

SHUJIRO TAKASE, SACHIO URASHIMA, MINORU YASUHARA and AKIRA TAKADA*

Division of Gastroenterology, Department of Internal Medicine, Kanazawa Medical University Uchinada, Ishikawa 920-02, Japan

*To whom correspondence should be addressed

Received 6 February 1989; accepted 20 June 1989

Aldehyde dehydrogenase (ALDH) V-A isozymes in saliva were detected in 96 patients with or without liver disease in order to clarify the relationships of the presence or absence of ALDH V-A isozymes to the metabolism of acetaldehyde (Ac-CHO) and alcoholic liver disease. The incidence of ALDH V-A deficiency was not different between the patients with alcoholic liver disease and those with non-alcoholic liver disease, nor between the patients with liver disease and without liver disease in no relation to alcohol misuse. Ac-CHO metabolism was not different between ALDH V-A deficient and non-deficient patients even in the ALDH I- deficient patients. These results indicated that ALDH V-A isozymes play virtually no role in the metabolism of Ac-CHO and its deficiency is not related to the development of alcoholic liver disease.


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