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© 1989 Medical Council on Alcohol

research-article

THE EFFECT OF CHRONIC ETHANOL INTAKE ON LEUCINE ABSORPTION FROM THE RAT SMALL INTESTINE

D. MARTINES*,{dagger}, A. I. MORRIS{ddagger},§ and D. BILLINGTON§

{dagger}Department of Gastroenterology, Royal Liverpool Teaching Hospital Prescot Street, Liverpool L7 8XW, U.K.
§Division of Biochemistry, School of Natural Sciences, Liverpool Polytechnic Byrom Street, Liverpool L3 3AF, U.K.

{ddagger} Author for correspondence

Received 15 April 1989; first review notified 20 June 1989; accepted 21 August 1989

Total (active + diffusion) absorption of leucine from the entire small intestine of rats or from segments of upper jejunum and lower ileum was unaffected by chronic ethanol feeding for 4 weeks. However, because of ethanol-induced mucosal atrophy, specific absorption (expressed per g dry weight of mucosa) was almost doubled in ethanol-fed rats. In the upper jejunum, the active component of leucine uptake was significantly greater in ethanol-fed rats 72% vs. 52%), whereas in the lower ileum the relative contributions of active uptake and diffusion were unaltered. We propose that the increase in active uptake in the upper jejunum is the result of a higher concentration of aged enterocytes having a greater transport capacity at the villus surface.


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