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© 1989 Medical Council on Alcohol

other

SUPEROXIDE DISMUTASE IN THE ERYTHROCYTES OF ACUTE ALCOHOLICS DURING DETOXIFICATION

H. K. ROOPRAI, O. E. PRATT*, G. K. SHAW and A. D. THOMASON

Department of Neuropathology, Institute of Psychiatry London SE5 8AF; Bexley Hospital, Bexley, Kent DA5 2BW; Greenwich District Hospital, London SE10 9HE, U.K.

*To whom cornspondence should be addressed at Department of Neuropathlogy, Institute of Psychiatry. London SE5 8AF, U.K.

Received 19 October 1989; accepted 3 November 1989

The activity of erythrocyte superoxide dismutase in acute alcoholic patients on admission does not form a single population but clusters in two groups either above or below the normal range. The values in both groups revert towards the normal after a week of treatment. The divergent activities of this free radical scavenging enzyme between the two groups could not be explained by differences in age, haematology or liver function tests but are likely to be acute responses, possibly to diverse drinking pattern in the period immediately preceeding admission.


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