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© 1989 Medical Council on Alcohol

other

SEARCH FOR ASSOCIATION BETWEEN MCV AND MISCARRIAGE, REFLECTING ETHANOL CONSUMPTION OR OTHERWISE

MARIA L. FERNANDEZ-FONTECHA and J. H. RENWICK

Department of Epidemiology and Population Sciences, London School of Hygiene and Tropical Medicine Keppel Street, London WC1E 7HT, U.K.

Received 17 August 1989; accepted 11 October 1989

In 38 miscarrying women and 38 pair-matched controls, all studied retrospectively, the mean pair-difference in MCV is +1.2 fl, P÷0.05 (one-tailed). As ethanol elevates MCV, this might weakly support the suggested role of ethanol in some miscarriages, although folate/B12 deficiencies cannot be excluded. The paper demonstrates only the feasibility of a first step in defining the possible role of ethanol in some miscarriages. It identifies a difficulty encountered from earlier attendance in the miscarrying group so that a later study could circumvent it and perhaps lead to a case for funding of a prospective enquiry into the dose-response relations of any association that might exist.


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