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© 1989 Medical Council on Alcohol

research-article

ALCOHOLISM AND DEPRESSIVE DISORDERS: IS CHOLINERGIC SENSITIVITY A BIOLOGICAL MARKER?

David H. Overstreet, Ph.D, David S. Janowsky, M.D and Amir H. Rezvani, Ph.D.1

Bowles Biomedical Research Laboratory, Center for Alcohol Studies and Department of Psychiatry University of North Carolina School of Medicine Chapel Hill, NC 27599

1Send Correspondence to: Dr. Amir H. Rezvani, Center for Alcohol Studies, UNC School of Medicine, CB#7175, Medical Research Bldg A, Chapel Hill, NC 27599

There is an overlap between alcoholism and depressive disorders. However, alcoholics tend to be resistant to the effects of cholinergic agonists, whereas depressives tend to be more sensitive. A recently developed animal model of depression which is more sensitive to cholinergic agonists is also more sensitive to the acute effects of ethanol. These consistent human and animal studies suggest that cholinergic challenges may be helpful in separating alcoholics from depressives.


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