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© 1989 Medical Council on Alcohol

other

EFFECT OF DIET ON [LACTATE]/[PYRUVATE] RATIOS DURING ALCOHOL METABOLISM IN MAN

D. MASCORD*, J. ROGERS{dagger}, J. SMITH{ddagger}, G. A. STARMER* and J. B. WHITFIELD{ddagger},§

*Department of Pharmacology, University of Sydney NSW 2006
{dagger}Department of Dietetics, Royal Prince Alfred Hospital Camperdown, NSW 2050
{ddagger}Department of Clinical Biochemistry, Royal Prince Alfred Hospital Camperdown, NSW 2050, Australia

§Author for correspondence

Received 5 January 1989; accepted 9 February 1989

Ten subjects received alcohol by intravenous infusion on two occasions, after fiveday periods on high- or low-carbohydrate diets. Blood [lactatej/[pyruvate] ratios were significantly higher during fasting alcohol metabolism after the low-carbohydrate, high-fat diet. The carbohydrate/fat balance in the diet may affect cytoplasmic-mitochondrial NADH transfer. Dietary composition may modify the metabolic changes caused by alcohol.


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