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© 1989 Medical Council on Alcohol

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THE [LACTATE]/[PYRUVATE] RATIO AND ALCOHOL METABOLISM: EXPERIMENTS WITH NALOXONE IN FASTING NORMAL MALE VOLUNTEERS

CHRISTOPHER J. MORGAN, ABDULLA A.-B. BADAWY*, D. ROGER THOMAS{dagger}, TIM G. DANDO{ddagger} and AMANDA KIRBY{dagger}

South Glamorgan Health Authority, Biomedical Research Laboratory Cardiff CF4 7XB, Wales
{dagger}Addiction Unit, Whitchurch Hospital Cardiff CF4 7XB, Wales
{ddagger}Department of Medical Biochemistry, University Hospital of Wales Heath Park, Cardiff CF4 4XW, Wales, U.K.

*Author for correspondence

Received 18 January 1989; accepted 7 February 1989

Naloxone administration to fasting normal male volunteers reverses the acute ethanol-induced increase in the blood [lactate]/[pyruvate] ratio, but fails to lower blood-ethanol concentration. The results are discussed in relation to factors affecting ethanol elimination and the mechanism of antagonism of acute alcohol intoxication by naloxone.


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