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© 1989 Medical Council on Alcohol

research-article

THE EFFECT OF PLACEBO IN THE ALCOHOL WITHDRAWAL STATE

FREDERICK J. LICHTIGFELD and MARK A. GILLMAN*

South African Brain Research Institute 173 Louis Botha Avenue, Orange Grove, 2192 Johannesburg, South Africa

*Author to whom correspondence should be addressed

Received 17 February 1987; accepted 15 November 1988

A double-blind study of the effects of 100% oxygen and medical air on the alcohol withdrawal state (AWS) showed no significant difference between the two conditions using a random sample of 50 subjects in each treatment group. However, both gases produced a therapeutic effect in over half the cases in each group. These results could be related to the possible opioid properties of the placebo response.


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