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© 1987 Medical Council on Alcohol

research-article

DRINKWATCHERS — DESCRIPTION OF SUBJECTS AND EVALUATION OF LABORATORY MARKERS OF HEAVY DRINKING

I. G. BARRISON*, J. RUZEK{dagger} and I. M. MURRAY-LYONS{ddagger}

*Gastrointestinal Unit St Mary's Hospital, London W2
{dagger}Gastrointestinal Unit ACCEPT Services, 200 Seagrave Road, London SW6 1RQ
{ddagger}Gastrointestinal Unit Charing Cross Hospital, London W6, U.K.

Received 16 June 1986; accepted 16 February 1987

Clinical examination and measurement of MCV and GGT were carried out on 124 self-referred ‘healthy’ Drinkwatchers, all of whom had consumed at least 80 g alcohol/day for more than 2 years. The majority (66.1%) were in social classes II and III.

Sixty-three subjects (54.1%) had a raised MCV, GGT or hepatomegaly. A raised MCV was significantly more likely to occur in men. Forty-five subjects (36.3%) had an enlarged liver of whom 17 had a normal MCV and GGT.

This study shows that MCV and GGT are poor screening tests for excessive alcohol consumption in ‘healthy’ subjects but, if used at all, MCV appears to be more sensitive in women and GGT in men. Neither test is an adequate substitute for a careful history and full clinical examination.


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