Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by KOTLINSKA, J.
Right arrow Articles by LANGWINSKI, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by KOTLINSKA, J.
Right arrow Articles by LANGWINSKI, R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1987 Medical Council on Alcohol

research-article

DOES THE BLOCKADE OF OPIOID RECEPTORS INFLUENCE THE DEVELOPMENT OF ETHANOL DEPENDENCE?

J. KOTLINSKA and R. LANGWINSKI*

Department of Pharmacodynamics Medical Academy, Staszica 4, 20–081 Lublin, Poland

* To whom correspondence and reprint requests should be sent

Received 9 July 1986; accepted 2 November 1986

We have tested whether the opioid antagonists naloxone (2 mg/kg), naltrexone (2 mg/kg) and diprenorphine (0.2 mg/kg), and the agonist morphine (4–8 mg/kg) given subcutaneously (10 min before ethanol for 7 days) modify the ethanol withdrawal syndrome (audiogenic seizures) following chronic ethanol intoxication in rats. We found that naloxone, naltrexone and diprenorphine modified the ethanol withdrawal syndrome. These findings do not rule out the possibility of a biochemical link between the action of ethanol and opiates at the level of opioid receptors.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.