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© 1986 Medical Council on Alcohol

research-article

REGIONAL DISTRIBUTION OF ZINC, COPPER AND LEAD IN BRAIN: (Na+-K+)-ADENOSINE TRIPHOSPHATASE CORRELATES OF ETHANOL ADMINISTRATIONPERIPHERAL NEUROPATHY AND MYOPATHY IN CHRONIC ALCOHOLISM

SHAFIQ-UR-REHMAN*

Department of Pharmacology, J. N. Medical College, Aligarh Muslim University Aligarh 202 001, India

Received 2 January 1986; accepted 16 June 1986

Zinc, copper and lead are known as inhibitory trace metals against brain (Na+-K+)-ATPase. Alcohol (4 g/kg intraperitoneally for 10 days, to rats) induced an elevated level of lead in the cerebral cortex and cerebellum, whereas that of zinc was elevated only in the latter region. Copper levels were found to be decreased in the hippocampus, amygdala and hypothalamus, but increased in the spinal cord. Zinc and lead contents were decreased in the amygdala and hypothalamus. The activity of (Na+-K+)-ATPase was enhanced in the hippocampus, amygdala and hypothalamus, but inhibited in the cerebral cortex and cerebellum. It is suggested that alcohol acts differentially on brain zinc, copper and lead concentrations and (Na+-K+)-ATPase activity.


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