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© 1986 Medical Council on Alcohol

research-article

PERIPHERAL NEUROPATHY AND MYOPATHY IN CHRONIC ALCOHOLISM

KERRY R. MILLS*, KEVIN WARD{dagger}, FINBAR MARTIN{dagger} and TIMOTHY J. PETERS{dagger},

*Department of Clinical Neurophysiology, The National Hospital for Nervous Diseases Queen Square, London, U.K.
{dagger}Division of Clinical Cell Biology, MRC Clinical Research Centre Harrow, Middlesex, U.K.

Address correspondence to: T. J. Peters, Division of Clinical Cell Biology, MRC Clinical Research Centre, Watford Road, Harrow, Middlesex HA1 3UJ, U. K.

Received 22 December 1985; accepted 14 May 1986

Nineteen chronic alcoholics referred for investigation of their medical complications and for alcohol re-education were subjected to quadriceps muscle biopsy and detailed peripheral nerve electrophysiological studies. Thirteen patients showed type II muscle fibre atrophy by histomorphometric analysis. The presence of atrophy did not correlate with peripheral neuropathy as determined by clinical examination or with objective indices of nutritional status. There was no association of muscle atrophy with neurophysiological evidence for neuropathy and both occurred independently of each other. It was concluded that chronic alcoholic myopathy was due to a toxic effect of ethanol on the muscle fibres and was not merely secondary to a peripheral neuropathy.


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