Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by BADAWY, A. A.-B.
Right arrow Articles by EVANS, M.
Right arrow Search for Related Content
PubMed
Right arrow Articles by BADAWY, A. A.-B.
Right arrow Articles by EVANS, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1983 Medical Council on Alcohol

research-article

OPPOSITE EFFECTS OF CHRONIC ADMINISTRATION AND SUBSEQUENT WITHDRAWAL OF DRUGS OF DEPENDENCE ON THE METABOLISM AND DISPOSITION OF ENDOGENOUS AND EXOGENOUS TRYPTOPHAN IN THE RAT

ABDULLA A.-B. BADAWY and MYRDDIN EVANS

South Glamorgan Health Authority, Addiction Unit Research Laboratory, Whitchurch Hospital Cardiff CF4 7XB, Wales, U.K.

Received 15 August 1983; Chronic administration of four drugs of dependence (ethanol, morphine, nicotine and phenobarbitone) enhances rat brain 5-hydroxytryptamine synthesis, whereas subsequent withdrawal causes an inhibition. These opposite effects are caused by correspondingly opposite changes in tryptophan availability to the brain brought about by altered hepatic catabolism of tryptophan by the action of liver tryptophan pyrrolase. The metabolism and disposition of an exogenously administered tryptophan load are also altered in similar fashions. The results are discussed briefly in relation to the role of liver tryptophan pyrrolase in depressive illness and the possible involvement of tryptophan and 5-hydroxytryptamine in drug dependence.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Alcohol AlcoholHome page
A. A-B Badawy, D. M. Doughrty, D. M. Marsh-Richard, and A. Steptoe
Activation of Liver Tryptophan Pyrrolase Mediates the Decrease in Tryptophan Availability to the Brain after Acute Alcohol Consumption by Normal Subjects
Alcohol Alcohol., May 1, 2009; 44(3): 267 - 271.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.