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© 1983 Medical Council on Alcohol

research-article

THE INFLUENCE OF SELECTIVE DOPAMINERGIC AND CHOLINERGIC AGONISTS AND ANTAGONISFS ON PRECIPITATED OPIATE ABSTINENCE

M. M. BEN-SRETI, J. P. GONZALEZ and R. D. E. SEWELL

Division of Pharmacology, The Welsh School of Pharmacy King Edward VII Avenue, Cardiff CF1 3NU, U.K.

Received 26 May 1983; The effects of selective dopaminergic and cholinergic agonists and antagonists on morphine abstinence were assessed. Morphine dependence in rats was induced by the subcutaneous implantation of morphine pellets, and abstinence was precipitated using the benzomorphan antagonist Mr-1452. Withdrawal was assessed by scoring and counting behavioural signs; body weight and temperature changes were also measured. Atropine, sulpiride and clozapine attenuated certain withdrawal signs, whereas oxotremonne and the D-1 receptor agonist compound SKF-38393 intensified the overall abstinence syndrome. In addition, treatment with the D-2 receptor agonist compound LY-141865, although blocking the majority of signs, uncovered other dose-dependent behaviours, e.g. copulatory mounting, stereotyped circling and aggression. Compound LY-141865 also attenuated the cholinergic withdrawal signs in a similar way to atropine. These results support the concept of an acetylcholine-dopamine link during opiate abstinence.


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