Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by FRAENKEL, H. M.
Right arrow Articles by VAN REE, J. M.
Right arrow Search for Related Content
PubMed
Right arrow Articles by FRAENKEL, H. M.
Right arrow Articles by VAN REE, J. M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1983 Medical Council on Alcohol

research-article

DESGLYCINAMIDE9-ARGININE8-VASOPRESSIN AND AMBULANT METHADONE-DETOXIFICATION OF HEROIN ADDICTS

H. MARIO FRAENKEL, GIJSJE VAN BEEK-VERBEEK, ALBERT J. FABRIEK and JAN M. VAN REE*

Jellinekcentrum, Amsterdam, The Netherlands
*Rudolf Magnus Institute for Pharmacology Utrecht, The Netherlands

Received 29 April 1983; The influence of sublingually administered desglycinamide9-arginine8-vasopressin (DGAVP) on ambulant methadone-detoxification of heroin addicts was investigated in two double blind, placebo controlled trials. It was found that treatment with DGAVP during the initial phase of methadone-detoxification of mild to moderate heroin addicts facilitated detoxification. These results and animal data concerning the interaction of DGAVP with heroin self-administration suggest that DGAVP may reduce the reinforcing action of heroin. DGAVP may have a similar effect on the action of cocaine, because the use of this latter drug by the addicts was also decreased by the peptide treatment.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Pharmacol. Rev.Home page
J. M. van Ree, M. A. F. M. Gerrits, and L. J. M. J. Vanderschuren
Opioids, Reward and Addiction: An Encounter of Biology, Psychology, and Medicine
Pharmacol. Rev., June 1, 1999; 51(2): 341 - 396.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.