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© 1983 Medical Council on Alcohol

research-article

CENTRAL NERVOUS NORADRENALINE METABOLISM IN ALCOHOLICS DURING LONG-TERM ABSTINENCE

STEFAN BORG*, HANS KVANDE*, DICK MOSSBERG* and GÖRAN SEDVALL{ddagger}

*Karolinska Institute, Department of Psychiatry, St. Görans Hospital Stockholm, Sweden
{ddagger}Karolinska Institute, Department of Psychiatry and Psychology, Karolinska Hospital Stockholm, Sweden

Received 28 April 1983; The levels of 3-methoxy-4-hydroxy-phenylethyleneglycol (MOPEG), the major noradrenaline metabolite in the central nervous system, were analyzed in the lumbar cerebrospinal fluid by a gas chromatographic-mass speetrometric method. MOPEG levels in institutionalized male alcoholies (alcohol-free for at least six weeks and without physical or mental disorders) were significantly lower than in healthy male volunteers. In patients with psychiatric symptoms the levels were higher than among patients without symptoms and did not deviate from the healthy controls. Assuming that MOPEG levels of the lumbar cerebrospinal fluid at least partly reflect the central nervous noradrenaline turnover in man, the present findings support earlier evidence of a connection between alcohol-related behaviour and central nervous noradrenaline metabolism.


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