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© 1983 Medical Council on Alcohol

research-article

METABOLIC FACTORS CONTROLLING VOLUNTARY ETHANOL CONSUMPTION IN MICE

P. V. TABERNER, J. W. UNWIN and D. M. CONNELLY

Department of Pharmacology, University of Bristol Medical School, University Walk Bristol BS8 1TD. U.K.

Received 3 November 1982; C57 BL mice exhibit an innate preference for alcohol solutions, in contrast to the LACG and BALB strains, which avoid alcohol. The C57 mice are less sensitive to the CNS depressant effects of alcohol given systemically and have higher liver alcohol dehydrogenase activity than the other two strains. C57 mice are mildly diabetogenic with higher plasma glucose levels than the other grains. When drinking ethanol, their plasma glucose concentration returns to normal. By giving oral hypoglycaemic drugs, it is also possible to reduce their glucose levels to normal. Under these circumstances the mice lose their preference for alcohol. It is proposed that plasma glucose may be an important factor in determining the alcohol preference of the C57 mice and could provide a model for alcohol drinking in diabetic patients.


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