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© 1983 Medical Council on Alcohol

research-article

EFFECT OF CHRONIC ETHANOL CONSUMPTION ON IN VIVO PROTEIN SYNTHESIS IN LIVERS FROM FEMALE AND MALE RATS FED TWO DIFFERENT DIET REGIMENS

ANNE SMITH-KIELLAND, LENE SVENDSEN, ATLE BESSESEN and JØRG MØRLAND

Department of Pharmacology, Institute of Medical Biology, University of Tromsø N-9001 Tromsø, Norway

Received 28 October 1982; Hepatic protein synthesis was studied in male and female rats fed ethanol-supplemented diets for 6–7 weeks. In one group (group 1), male rats were fed an all-liquid diet with 36% of the energy as ethanol. The controls were pair-fed with carbohydrate replacing ethanol isoenergetically. The second group of male rats (group 2) was given a mixture of solid and liquid diets. The solid food was given ad libitum and was supplemented with either an ethanol-containing liquid (20–30% of energy as ethanol) or isoenergetic amounts of lipid. Female rats (group 3) received the same diet regimen as group 2. Rates of hepatic protein synthesis were measured after a 12–18 hr fast by a 32 min continuous infusion of 3H-valine. Specific precursor radioactivity (valyl tRNA) was calculated from valine specific radioactivities and concentrations in intra- and extracellular water at 12, 22 and 32 min.

The rates of protein synthesis were lower in all three groups of ethanol-treated rats than in controls. In group 1, ethanol feeding resulted in protein accumulation, and the plasma protein concentration was significantly lower at 20 and 32 min. In conclusion, female and male rats fed various diets were susceptible to the same inhibitory effect of chronic ethanol consumption on hepatic protein synthesis.


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Am J Physiol Endocrinol Metab, July 1, 2008; 295(1): E3 - E9.
[Abstract] [Full Text] [PDF]


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